After enzyme treatments, the supernatants showed first- or second-order inhibitory effects on K. ![]() However, antibacterial activity disappeared entirely at pH 7.0. The results showed that the supernatants had good heat stability. Anti-adhesion and anti-invasion activities against urinary tract pathogens were evaluated by SV-HUC-1 uroepithelium cell culture. Anti-growth activity against urinary tract pathogens was evaluated by co-culture inhibition assay using seven LAB strains. ![]() We studied the effect of heat, pH and enzyme treatment on the inhibitory activity of LAB strain supernatants. ![]() We screened 370 LAB strains using spent culture supernatants by inhibition zone assay to assess their antimicrobial effects. The purpose of the present study was to identify strains of lactic acid bacteria (LAB) which could be used as alternatives to antibiotics for the treatment of urinary tract infections because of their ability to inhibit urinary tract pathogens ( Klebsiella pneumoniae BCRC 10694 and Gardnerella vaginalis BCRC 17040). Urinary tract infections are the most common infectious diseases in babies and the elderly and are often acquired as nosocomial infections.
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